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DynamITE aims to manipulate drug transport in the human body by understanding the dynamics of transport proteins. It employs structural mass spectrometry to identify modulators that can enhance or block drug transport, with applications in antibiotic resistance and drug delivery.
The therapeutic effect of a drug is largely determined by how effectively it reaches its site of action.
Drug distribution in the human body is defined by an intricate network of transporters, offering potential for dynamically controlling where a drug spends most of its time.
DynamITE aims to provide the tools to manipulate this ""highway network"" of drug transport at will.
DynamITE will exploit the common mechanism shared by transporters, that is the alternating-access.
Every transporter must…
UNIVERSITE LIBRE DE BRUXELLES
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