CORDIS Project
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This project investigates how Mycobacterium tuberculosis replicates within human cells, focusing on the interactions between the bacteria and host cell organelles. By employing advanced imaging techniques, the research aims to identify critical components that influence bacterial replication and the pathways leading to…
Mycobacterium tuberculosis (Mtb) is a very successful intracellular pathogen: in 2014, tuberculosis (TB) caused 1.5 million human deaths (World Health Organisation).
To cause disease and disseminate to other hosts, Mtb needs to replicate within human cells.
In spite of its enormous relevance for TB pathogenesis, the precise sites of Mtb replication in host cells remain unknown.
This surprising gap in knowledge is in part due to the lack of appropriate imaging technologies that have precluded com…
THE FRANCIS CRICK INSTITUTE LIMITED
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