CORDIS Project
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This project examines the mechanisms of intestinal stem cell regulation in Drosophila to understand gut homeostasis. The findings aim to provide insights applicable to human health, particularly in diseases like colorectal cancer and inflammatory bowel disease.
Cells in intestinal epithelia turn over rapidly due to aging, damage, and toxins produced by the enteric microbiota.
Gut homeostasis is maintained by intestinal stem cells (ISCs) that divide to renew the intestinal epithelium, but little is known about how ISC division and differentiation are coordinated with the loss of spent gut epithelial cells.
This proposal addresses the mechanisms of dynamic self-renewal in the intestine of Drosophila.
Our recent work has outlined a paradigm explaining int…
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
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