CORDIS Project
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This project explores the regulation of the cytoplasmic dynein complex, crucial for cellular transport and division. Using the nematode C. elegans, it aims to uncover how various proteins interact with dynein, enhancing our understanding of its diverse functions and implications for neurodegenerative diseases.
The megadalton cytoplasmic dynein complex, whose motor subunit is encoded by a single gene, provides the major microtubule minus end-directed motility in cells and is essential for a wide range of processes, ranging from the transport of proteins, RNA, and membrane vesicles to nuclear migration and cell division.
To achieve this stunning functional diversity, cytoplasmic dynein is subject to tight regulation by co-factors that modulate localization, interaction with cargo, and motor activity. A…
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