CORDIS Project
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This project investigates the structure and function of the dynein motor protein tail, which is crucial for cargo transport within cells. By employing advanced techniques like cryo-electron microscopy and recombinant expression, the research aims to enhance understanding of dynein's role in cellular movement and its im…
Movement is a defining characteristic of life at the sub-cellular level.
Dynein is one of the motor proteins that power this movement.
It carries a wide range of cargos and dynein dysfunction has been implicated in many human diseases.
Unlike other motors only one cytoplasmic dynein exists which suggests that it has unique mechanisms for controlling specificity i.e. how it carries cargo to the right place at the right time.
In order to understand these mechanisms detailed structural knowledge of…
MEDICAL RESEARCH COUNCIL
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