CORDIS Project
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The project investigates how exposure to environmental pollutants during pregnancy and early childhood affects long-term health outcomes. By creating a mother-child cohort and conducting both human and animal studies, it aims to understand the mechanisms linking pollutants to chronic diseases.
The DOHaD (Developmental Origins of Health and Disease) hypothesis states that, because of developmental plasticity, in utero and early postnatal stressors can increase chronic disease risk in childhood and later.
Alterations of epigenetic marks, impacting on gene expression, are one mechanism that could explain such long-term impact.
These hypotheses have so far been tested mostly in animals, and little for atmospheric pollutants, for which animal evidence is scarce.We aim to characterize the i…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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