CORDIS Project
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This project investigates how epigenetic modifications, specifically metastable epialleles, influence body weight regulation and susceptibility to metabolic diseases. By analyzing human samples and stem cells, it aims to uncover the relationship between methylation variability and phenotypic differences, providing insi…
The development of obesity in industrial and low-and middle-income countries is leading to a severe burden for patients and health care systems based on associated comorbidities as cardiovascular diseases and type 2 diabetes mellitus.
Apart from the genetic background, epigenetic modifications like DNA methylation are supposed to play an important role for body weight regulation.
So far, epigenome-wide association studies were not able to elucidate this relationship, as most methylation differen…
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