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The EaSYFUN project investigates the role of the protein elongation factor 1A (eEF1A) in synucleinopathies, such as Parkinson's disease. By utilizing advanced genome editing and human stem cell models, the project aims to understand eEF1A's function at synapses and its impact on disease progression.
Synucleinopathies are neurodegenerative conditions characterized by an accumulation of the protein alpha-synuclein, including Parkinson's disease and dementia with Lewy bodies. A long asymptomatic phase precedes the onset of invalidating symptoms.
Early diagnostics and treatments are hampered by an incomplete understanding of the pathophysiological mechanisms.
The Host has recently identified the synaptic depletion of protein elongation factor 1A (eEF1A) at early stage of the disease.
In EaSYFUN…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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