CORDIS Project
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This project investigates why ebolaviruses cause severe disease in some species but not others. By developing genetically modified mice that mimic human immune responses, researchers aim to study the infection dynamics and pathogenic mechanisms of ebolaviruses.
Ebolaviruses comprise five virus species of which at least three are highly pathogenic for humans.
Other mammalian species such as non-human primates, forest antelopes and pigs are susceptible to ebolavirus infection with different degree of severity.
However, bats and laboratory mice are entirely resistant to ebolaviruses.
Why do ebolaviruses cause severe disease in some species but not others?
This question, which is paramount to understand ebolavirus pathogenesis is the central question of ou…
BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN
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