CORDIS Project
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The ECONOMICS project investigates the structure and dynamics of microRNA-34a complexes with messenger RNA to enhance its specificity as a cancer treatment. By using NMR spectroscopy and molecular dynamics simulations, the project aims to improve the effectiveness of RNA-based therapies for various cancers.
microRNA-34a (miR-34a) is mis-regulated in ~75% of cancers and is considered a promising drug target.
In a recent clinical trial, miR-34a was used against terminal liver cancer showing promising result with remission of 3 patients.
However, mortality remained high and was attributed to its ability to target multiple mRNAs.
Project ECONOMICS will investigate this issue by elucidating the underlying structure and dynamics of multiple miR-34a:mRNA complexes using NMR spectroscopy and molecular dyna…
UPPSALA UNIVERSITET
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Sweden, Stockholm
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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