CORDIS Project
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The ECoToL project investigates a novel antiviral system in bacteria, known as Eleos, to understand its evolutionary origins and mechanisms. By analyzing genome data and exploring its similarities with eukaryotic immune systems, the project aims to enhance our understanding of immunity across different life forms.
Sensing viral infections and mounting a response is crucial for all domains of life.
Many immune mechanisms in higher eukaryotes were thought to be evolutionary innovations, but recent research reveals that some components of the innate immune system have evolved from bacterial genes.
Eleos, a novel anti-viral system in prokaryotes, shares similarities with eukaryotic GIMAPs (GTPase immunity-associated proteins), yet their evolutionary history and anti-viral mechanisms remain unknown.ECoToL's ob…
INSTITUT PASTEUR
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