CORDIS Project
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This project investigates how specialized endothelial cells adapt their characteristics in response to mechanical, biochemical, and genetic factors in their environment. By studying brain and aortic valve endothelial cells, the research aims to enhance understanding of their heterogeneity and improve strategies for tar…
Endothelial cells (ECs) specialize towards tissue-specific needs by shaping their phenotypes in response to microenvironmental stimuli, becoming a highly heterogeneous population.
Overlooking the EC heterogenic nature most likely underlies the low efficacy and side-effects of broad-spectrum treatments for vascular bed-specific diseases.
However, little is known on the interplay between the factors regulating the EC signatures, and tissue engineering research has essentially used standard and poo…
KATHOLIEKE UNIVERSITEIT LEUVEN
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