CORDIS Project
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This project develops an independent system for synthesizing unnatural polymers in living cells. It aims to enhance the incorporation of non-standard building blocks into proteins, improve mutagenesis efficiency, and explore new genetic codes, potentially leading to novel cellular functions.
We are building a parallel and independent (orthogonal) translational machinery for the encoded biosynthesis of unnatural polymers in living cells.
The orthogonal translation system has many potential applications beyond those possible with the natural translation system:
I propose to use it: 1) To expand the chemical scope of monomers that can be polymerized by the ribosome in living cells, allowing the incorporation of monomers with unnatural backbones into proteins; 2) To increase the efficie…
MEDICAL RESEARCH COUNCIL
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