CORDIS Project
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This project aims to understand how alternative splicing influences the differentiation of mammalian embryos. By analyzing RNA sequencing data and employing CRISPR technology, it seeks to identify key exons that regulate pluripotency and early development.
Understanding how the differentiation potential of the mammalian embryo gets restricted during development is a key question in the embryology and stem cell fields.
Alternative splicing (AS) is the process by which different exons are selected in precursor mRNAs to generate multiple protein products.
Recent studies have shown that 95% of human multiexonic genes undergo AS, however little is known regarding its role in modulating pluripotency and differentiation.
The aim of this project is to stu…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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