CORDIS Project
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This project investigates the human glymphatic system, which is crucial for metabolite clearance during sleep. It aims to link glymphatic flow to cognitive impairments from sleep loss and explore the potential of Carvedilol to enhance this flow, offering new insights into sleep disorders and Alzheimer's disease.
Sufficient sleep is a key determinant of health, and sleep loss is associated with severe health risks.
Nevertheless, the reason for why we sleep is not yet understood.
Recently, a molecular function of sleep was described in rodents.
The ‘glymphatic system’ (GS) is a sleep dependent macroscopic pathway of the brain that facilitates the removal of metabolites, including amyloid-beta.
This project will for the first time reveal a sleep-driven human GS and show whether glymphatic flow (GF) can be…
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