CORDIS Project
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This research focuses on understanding how embryonic stem cells maintain their identity during cell division. It explores the role of transcription factors in preserving gene activity, challenging traditional views on gene repression in stem cell biology.
The preservation of cell identity depends on the maintenance of gene expression programs through mitosis.
Generally, this is mediated by epigenetic systems of repression involving Polycomb proteins and H3K9 and DNA methyltransferases.
Pluripotent Embryonic Stem (ES) cells constitute an exception as abrogation of these systems does not lead to detrimental consequences, with defects appearing only during differentiation.
This is particularly surprising since ES cells maintain their transcriptome a…
INSTITUT PASTEUR
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