CORDIS Project
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The project aims to identify chromatin-modifying complexes involved in chromosome remodeling during oocyte development. By understanding these mechanisms, the research seeks to shed light on the aging of germline cells and its impact on fertility, particularly as maternal age increases.
Faithful transfer of genetic material is critical for the success of all cell divisions.
Yet, as the organism ages this process becomes more error-prone, leading to aneuploidic daughter cells due to mis-segregation of chromosomes.
This can lead to cancer in mitotic cells, and in the female germline it leads to reduced fertility and exponential increase in miscarriages and birth defects already at the third decade of life.
In humans, all the oocytes begin their development in-utero but arrest for…
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