CORDIS Project
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This project focuses on enhancing cancer immunotherapy by targeting tumor-associated macrophages to shift them from an immunosuppressive state. By inhibiting a specific enzyme, the project aims to improve immune cell infiltration and effectiveness against tumors, particularly in melanoma and other cancers.
The field of cancer immunotherapy has witnessed exciting therapeutic advances in the last decade, but still a large fraction of patients is not responsive and several cancer types are refractory to this therapy.
The presence of a strongly immunosuppressive environment is a likely explanation for the suboptimal efficacy of immunotherapy.
One of the most abundant and immune suppressive population in the tumor microenvironment (TME) is represented by tumor-associated macrophages (TAMs).
Therefore,…
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