CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of Lgi4, a protein expressed by Schwann cells, in the development and function of peripheral nerves. By exploring its interaction with Adam22, the research aims to clarify mechanisms affecting axonal sorting and myelin formation, which could lead to new therapies for nerve repair.
Schwann cells (SC) are the most important accessory cells to neurons in the peripheral nervous system (PNS) and are involved in every aspect of nerve structure, function and regeneration.
Dr Meijer’s group has identified a novel SC expressed factor, Lgi4, involved in nerve development and function.
The Lgi4 gene is mutated in a natural mouse mutant called Claw Paw, which exhibits delayed axonal sorting and hypomyelination in the PNS.
Lgi4 is a member of a small family of secreted proteins mainly…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
