CORDIS Project
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This project focuses on developing a new method for synthesizing benzofuroindolines, a compound related to a potent anti-cancer agent. By creating a library of these compounds, the research aims to identify simplified analogs that maintain the therapeutic potential of diazonamide A while being easier to produce.
The objectives of this project are the development of A new and efficient asymmetric oxidative coupling reaction between phenols and indoles for the synthesis of benzofuroindolines analogs of diazonamide A and the biological evaluation of a
library of this family of compounds.The benzofuroindoline core is a unique motif found in the natural products diazonamide A, a very potent anti-cancer agent (<5 nM against various cell lines) which may have clinical utility for cancer
therapy since it is as…
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