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ELECTROSULF focuses on developing a new method for modifying peptides through electrochemical sulfonylation of lysine. This innovative approach aims to enhance the pharmaceutical applications of peptides by streamlining the introduction of sulfonamide groups.
Peptides are important molecules, ubiquitous in biological systems.
Their relevance in the pharmaceutical sector is proven by the constant increase which the global market of peptide-based drugs is experiencing in the last years.
As a consequence, several methods have been developed to modify peptides (e.g. condensation, cross-coupling, transition-metal catalysis, and photocatalysis), being lysine with its free amine one of the most preferred handles used by chemists to introduce a new moieties,…
TECHNISCHE UNIVERSITEIT EINDHOVEN
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