CORDIS Project
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This project investigates how B cells originating in early life influence the adult immune system. It focuses on understanding the mechanisms of immune programming and the role of early life derived B cells in shaping long-term immune responses and host protection.
This proposal addresses the combined role of early life derived B cells in the adult immune system.
Neonatal immune imprinting is now well-established concept.
It emphasizes the importance of the early life window to establish host-microbial mutualism and the set-point for immune responsiveness later in life.
However, the cellular and molecular mechanisms underlying this immune programming are not well understood.
Despite the ability of B cells to integrate and store complex immunological memory…
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