CORDIS Project
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This project investigates the role of the elongase enzyme Elovl6 in brown adipose tissue, focusing on how fatty acid chain length affects lipid oxidation and energy balance. Using genetically modified mice and cellular techniques, the research aims to clarify Elovl6's involvement in thermogenesis and body weight regula…
Obesity is the result of a mismatch between energy intake and energy expenditure.
Excess calories will end up as fatty acids which can be stored, exported to other tissues, oxidized or transformed to lipid metabolites.
Little is known of how these lipids are targeted to these various fates.
Brown adipose tissue (BAT) is an organ with high rates of lipid oxidation and large cellular lipid stores, making it an ideal organ to investigate lipid targeting.
The elongase Elovl6 can elongate mono and po…
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