CORDIS Project
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This project aims to improve the delivery of therapeutic agents into cells using a novel fluorescent probe that can be switched on and off with electric potential. This method seeks to enhance the study of cell-penetrating peptides and their effectiveness in drug delivery.
In current drug development, the visualization of therapeutic-agent translocation to the cell interior represents one of the essential problems.
The transport across cellular membranes is frequently executed by cell-penetrating peptides (CPPs), and the process is routinely studied with fluorescence microscopy when the CPP is attached to a fluorescent marker.
Nevertheless, the use of existing labelled CPPs is connected with several drawbacks.
Especially, bonding of CPPs to the external face of th…
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