CORDIS Project
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This project investigates the role of Polo-Like Kinases in phosphorylating alpha-synuclein, a protein linked to Parkinson's disease. By combining laboratory and animal studies, it aims to clarify how this phosphorylation affects protein aggregation and neurodegeneration, potentially leading to new treatment targets for…
Increasing evidence suggest that alpha-synuclein (a-syn) phosphorylation plays an important role in the regulation of a-syn aggregation, Lewy Bodies (LBs) formation and neurotoxicity in Parkinson’s disease (PD) and related synucleopathies.
However, the exact kinase(s) responsible for phosphorylating a-syn and the relationships between phosphorylation, a-syn fibrillogenesis, LB formation and cell death have not been fully elucidated.
Preliminary data in our Laboratory have pointed out a Polo-Like…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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