CORDIS Project
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This project investigates the link between influenza virus infection and the development of small airway fibrosis in chronic obstructive pulmonary disease (COPD). By using patient-derived cell models, the research aims to identify molecular mechanisms that contribute to disease progression.
Influenza virus infects the airway epithelium.
The connective tissue underneath the epithelium consists of extracellular matrix (ECM) produced mainly by fibroblasts.
Small airway fibrosis, characterized by fibroblast activation and excessive deposition of ECM, is emerging as the key driver of the progression of chronic obstructive pulmonary disease (COPD), a very common and life-threatening lung disease for which no cure exists.
Irreversible progression of COPD is often triggered by influenza vi…
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
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