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The EMcapsulins project develops a new suite of genetic reporters for electron microscopy, enabling detailed visualization of neuronal types and their activation history. This technology aims to bridge structural brain diagrams with functional data, enhancing our understanding of brain connectivity and signaling.
The biological engineering project EMcapsulins will create the first suite of multiplexed genetic reporters for electron microscopy (EM) to augment today’s merely structural brain circuit diagrams (connectomes) with crucial information on
neuronal type and activation history.My team will generate this new toolbox based on genetically encoded nanocompartments of the prokaryotic ‘encapsulin’ family that we have recently shown to enable genetically controlled
compartmentalization of multicomponent…
TECHNISCHE UNIVERSITAET MUENCHEN
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