CORDIS Project
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This project investigates the structural biology of Cullin-RING Ligases, which are crucial for regulating various cellular processes. Using cryoelectron microscopy, it aims to elucidate the mechanisms of these ligases and their regulation by the COP9 signalosome.
The components of the Cullin-RING Ligase (CRLs) E3 ubiquitin ligase family play key roles in a wide range of cellular processes including stress response, signal transduction, apoptosis and cell cycle progression, and accordingly, defects in their function and/or regulation are prominent in many pathologies including cancer.
The modular CRL architecture is centred upon one of seven different cullin scaffold proteins which associate on one side with a RING protein that acts as receptor for an E2…
INSTITUTE OF CANCER RESEARCH: THE ROYAL CANCER HOSPITAL LBG
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