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EMERGE explores the evolution of gene regulation mechanisms that contribute to phenotypic diversity in multicellular animals. By studying sex chromosome dosage compensation, the project aims to uncover the underlying principles of gene expression regulation across various species.
There is a remarkable diversity of phenotypes among multicellular animals, including differences between males and females. A major driver of phenotypic variation stems from differences in gene regulation.
The evolution of these regulatory mechanisms is a central, yet unresolved question in biology.
Sex chromosome dosage compensation (SCDC) is an epigenetic process that equalizes sex chromosomal gene expression between males and females. EMERGE uses SCDC as a model to uncover how and why epigene…
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