CORDIS Project
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This project focuses on pulmonary arterial hypertension (PAH) by investigating the metabolic profiles of lung endothelial cells. Using single-cell RNA sequencing, it aims to identify cell heterogeneity and potential metabolic targets for new therapies to improve patient outcomes.
BACKGROUND:
Pulmonary arterial hypertension (PAH) is a devastating disease, characterized by a dramatic increase in pulmonary arterial pressure and an intense remodeling of small intrapulmonary arteries.
With the exception of the lung replacement therapy, PAH remains an incurable disease with poor survival.
Recent studies have shown that in PAH, rewiring of the metabolism of the lung endothelial cells (ECs) promotes vascular remodeling.
However, these studies overlooked that lung ECs are exposed…
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