CORDIS Project
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This project investigates how specific endosomes influence Notch signaling during asymmetric cell division in fruit flies. By analyzing endosomal dynamics and their impact on stem cell behavior and tumor formation, the research aims to enhance understanding of cellular communication and its implications for cancer biol…
Recent Drosophila reports show that directional Notch signalling during asymmetric cell division is mediated by asymmetric endocytic trafficking.
Unpublished data from the host lab showed that directional Notch signalling is initiated by the directed targeting towards the signal-receiving cell of specific endocytic compartments, the Sara endosomes, which carry the receptor Notch and its ligand Delta. I will combine automated quantitative analysis of the movement of these endosomes with an RNAi s…
UNIVERSITE DE GENEVE
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