CORDIS Project
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This research investigates the genetic factors contributing to coronary artery disease by identifying and characterizing single nucleotide polymorphisms associated with the condition. The focus is on understanding the role of enhancers in relevant cell types to improve disease prediction and treatment.
In recent years, genome-wide association studies (GWAS) have discovered hundreds of single nucleotide polymorphisms (SNPs) which are significantly associated with coronary artery disease (CAD).
However, the SNPs identified by GWAS explain typically only small portion of the trait heritability and vast majority of variants do not have known biological roles.
This is explained by variants lying within noncoding regions such as in cell type specific enhancers and additionally ‘the lead SNP’ identif…
UNIVERSITY OF EASTERN FINLAND (UEF)
ITA-SUOMEN YLIOPISTO
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