CORDIS Project
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The project investigates amoeboid motility in cancer cells and endothelial cells, proposing a new concept of 'amoeboid angiogenesis.' It aims to identify shared mechanisms that facilitate cancer invasion and blood vessel formation, potentially leading to improved cancer therapies.
Unlike mesenchymal migration, the amoeboid motility doesn’t require proteases and is an opportunistic movement of cancer cells which allows cells to glide through, rather than degrade, ECM barriers, using movements based on adaptations of the cell body.
Preliminary experiments we conducted using a mixture of physiologic inhibitors of serine-proteases, metallo-proteases and cysteine-proteases, thus mimicking a physiological environment, showed no differences in vessel formation for both Endotheli…
UNIVERSITA DEGLI STUDI DI FIRENZE
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LOS ANGELES UCLA SANTA BARBARA UCSB DAVIS UCD RIVERSIDE UCR SAN DIEGO UCSD SANTA CRUZ UCSC IRVIN
United States, Berkeley
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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