CORDIS Project
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This project investigates the integration of giant viruses into the genomes of eukaryotes, focusing on how this process affects host evolution and immunity. By using Hydra as a model organism, it aims to understand the epigenetic regulation of these viral integrations and their implications for gene family expansions.
Giant viruses, renowned for their exceptionally large genomes with thousands of genes, are increasingly being identified as integrated elements within eukaryotic genomes.
This seemingly paradoxical process of endogenization is significant, as it represents a pathway for large-scale lateral gene transfer in eukaryotes.
However, the initial integration of viral DNA can impose severe evolutionary costs, potentially being lethal for the host.
The overarching hypothesis of this proposal is that the g…
QUEEN MARY UNIVERSITY OF LONDON
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