CORDIS Project
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This project investigates the role of the Myo1b protein in shaping sorting endosomes, which are critical for cellular trafficking. It aims to uncover the molecular mechanisms by which Myo1b influences endosomal morphology and the sorting of proteins.
Sorting events that occur in endosomes are very important for cellular trafficking of proteins and membranes along the endocytic pathway.
The shape of sorting endosomes plays a major role in their function.
However, the molecular mechanisms that control the shape of sorting endosomes are far from being elucidated.
Motors and cytoskeleton can influence the shape of membranes, especially of high curvature, by establishing tension on membranes. I propose to study the role of an actin cytoskeleton-m…
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