CORDIS Project
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This project explores the role of gluconeogenesis in endothelial cells and its impact on blood vessel formation, particularly in the context of cancer. It aims to uncover metabolic pathways that could be targeted to inhibit pathological angiogenesis.
Angiogenesis promotes tumor progression and metastasis; unfortunately current anti-angiogenic strategies targeting endothelial growth factors suffer from limited efficacy and toxicity.
The host laboratory pioneered the novel concept that blood vessel forming endothelial cells (ECs) reprogram their metabolism to become glucose-addicted and rely on glycolysis to generate ATP required for angiogenesis.
Furthermore, to increase biomass production and maintain redox homeostasis, ECs shunt glycolytic…
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