CORDIS Project
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This research project focuses on understanding the biogenesis and regulation of secretory organelles in apicomplexan parasites, which are crucial for their invasion of host cells. By analyzing these organelles, the project aims to identify novel pathways that could lead to new treatment options against these pathogens.
Apicomplexan parasites invade the host cell in an active process that involves gliding motility, formation and movement through the moving junction (MJ) and establishment of a prasitophorous vacuole (PV) around the parasite.
In order to invade the host cell they employ an arsenal of virulence factors derived from the specialised secretory organelles; the micronemes, rhoptries and dense granules that are sequentially secreted during the invasion process.While the content of the secretory organell…
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