CORDIS Project
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EnergizeTau examines the role of Tau protein in neurodegenerative diseases, proposing that Tau's mislocalization is a response to energy stress in neurons. The project aims to understand how Tau affects neuronal metabolism and its implications for disease pathology.
The intraneuronal somatodendritic ""missorting"" and aggregation of Tau are pathological hallmarks in neurodegenerative diseases (NDDs) like and Alzheimer's disease (AD), and are thought to be drivers of neurotoxicity.
That NDDs manifesting with Tau ""missorting"" present with (neuro)metabolic abnormalities, often prior to pathology onset, is largely overlooked.
EnergizeTau investigates the ground-breaking new idea that the somatodendritic re-sorting of Tau is a physiological response to bioener…
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV
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