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The GuT Memory project investigates how intestinal T cells develop memory in response to gut bacteria, aiming to understand their role in inflammatory bowel disease and vaccine design. By using engineered bacteria to study T cell responses, the project seeks to uncover mechanisms that influence immune memory and tolera…
A detailed understanding of intestinal T cell memory is crucial for novel treatments against inflammatory bowel disease but also for efficient vaccine design.
Th cells induced by the gut microbiota are important for pathogen defence and tolerance, but it is unknown whether they form immunological memory characterised by long-term, antigen-independent maintenance.
This has been due to the technical inability of disconnecting T cell induction from bacterial persistence in the gut.
The GuT Memory p…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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