CORDIS Project
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This project aims to enhance the effectiveness of lipid nanoparticle-mRNA therapies for advanced breast cancer by improving their ability to escape endosomes. It focuses on designing targeted nanoparticles that can better deliver genetic material to cancer cells while minimizing toxicity.
There is a strong need for personalised genetic medicines for the treatment of advanced breast cancer. LNP-mRNA nanomedicines have already been proven as safe and cost effective in the SARS-CoV-2 vaccines.
However, cancer treatments often require (i) repeat dosing (ii) controlled immune response (iii) adaptability to combat drug resistance.
There are several LNP-RNA clinical cancer trials ongoing, many of which have reported challenges with toxicity, performance and specificity (off target effec…
KUNGLIGA TEKNISKA HOEGSKOLAN
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