CORDIS Project
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This project investigates how specific oncogenic fusion genes contribute to sarcoma development in distinct cellular environments. By engineering human pluripotent stem cells, the research aims to create disease models that help understand the mechanisms of fusion-driven sarcomagenesis and facilitate the testing of new…
One of the unsolved problems in cancer biology is why and how do certain oncogenic driver genes promote cancer in one cellular context but not in another.
This project focuses on fusion oncogenes relevant to sarcomas, which are sarcoma type-specific and tumorigenic only in certain cellular states.
By combining cell fate engineering of human pluripotent stem cells (hPSCs) with forced expression of sarcoma-linked fusions, I will systematically probe the cellular contexts and molecular mechanisms o…
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