CORDIS Project
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This study focuses on understanding the replication process of human enteroviruses, particularly Coxsackievirus B3, which causes viral myocarditis. By using advanced imaging techniques, the project aims to reveal the structural organization of viral replication complexes within infected cells, which could inform future…
The aim of this study is to gain structural insights into the genome replication of human enteroviruses (EVs), specifically Coxsackievirus B3 which is the leading cause of viral myocarditis. EVs drastically reorganize the internal membranes of a cell within hours of infection, generating replication complexes (RCs), which are the sites of viral genome replication.
Some molecular determinants of RC morphogenesis have been identified, and resin-embedding EM has indicated the drastic membrane remod…
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