CORDIS Project
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This project investigates the process of entosis, where one cell engulfs another, particularly in cancer contexts. It aims to uncover the molecular mechanisms behind this phenomenon and its potential role in tumor suppression.
Entosis is a recently discovered process of live cell engulfment in which one epithelial cell is completely internalised by another, forming a 'cell-in-cell' structure.
The majority of engulfed cells are killed and digested by their host, in an unusual form of cellular cannibalism.
Entosis is commonly observed in human tumours and entotic cell killing represents a novel mode of tumour suppression.
Although cell-in-cell structures have been noted by pathologists for decades, the molecular and c…
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