CORDIS Project
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This project investigates the role of human endogenous retrovirus envelope proteins in various diseases by developing a high-throughput screening platform for specific antibodies. It aims to identify disease-specific antibody responses and understand the impact of genetic diversity on these responses, ultimately enhanc…
Human endogenous retroviruses (HERV) are highly repetitive sequences that are remnants of viral infections successfully integrated in the genome.
Aberrant expression of HERV envelope (Env) proteins is frequent in cancer, autoimmunity, neurodegeneration, and infection and has been associated with antibody responses.
However, we do not know if all HERV Env proteins contribute to antibody responses or what the prognostic impact of HERV Env-specific antibodies is.
Thus, the objectives of this propos…
THE FRANCIS CRICK INSTITUTE LIMITED
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