CORDIS Project
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This project investigates the isolation and characterization of endothelial progenitor cells derived from various sources, including umbilical cord blood and bone marrow. It aims to enhance vascular regeneration through systemic delivery and the use of chemoattractant molecules to improve cell homing to ischemic sites.
Introduction:
Transdifferentiation of umbilical cord (UC) blood, bone marrow (BM) and vessel derived stem cells into endothelial progenitors has been reported both in vitro and in vivo.
Encouraging but limited success with these studies suggested the need for identification of more versatile populations of endothelial progenitors or signaling pathways to improve their homing to ischemic sites seeking angiogenesis and neovascularization.
Objective:
We propose to isolate and characterize in vitro…
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