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The EPI-CART project aims to enhance CAR T cell therapy for blood cancers by focusing on epigenetic regulation. It investigates patient-specific responses and develops a platform to engineer improved CAR T cells for challenging cancers, utilizing advanced profiling techniques and in vivo models.
The dramatic efficacy of CAR T cell therapy in certain hematopoietic malignancies provides clinical validation of a groundbreaking paradigm:
Human cells can be engineered into purpose-built therapeutic agents by genetically introducing artificial regulatory programs.
The EPI-CART project will focus on epigenetic regulation in CAR T cell therapy – an important but underappreciated aspect of all cell-based therapies.We will investigate the regulatory dynamics during CAR T cell therapy in unprecede…
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