CORDIS Project
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This project explores the role of the blood-brain barrier in epilepsy, focusing on how the P2X7 receptor affects its integrity during seizures. The goal is to identify new treatment strategies targeting this receptor.
Epilepsy is the most common chronic neurological disorder, affecting ~50 million people.
Major challenges in epilepsy include non-responsiveness to treatment and no effect on disease progression provided by anti-epileptic drugs.
Over the past decade, particular attention has been paid to dysfunction of cerebral vasculature and inflammatory processes as important players in epileptogenic processes, with a specific emphasis on failure of the blood–brain barrier (BBB).
The BBB is a complex cellular…
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