CORDIS Project
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This project investigates how pausing stem cell differentiation and allowing cell growth can improve the production of pancreatic cells. By studying the role of specific proteins in enhancer network reorganization, the research aims to develop more effective protocols for generating pancreatic endoderm and endocrine ce…
Pluripotent stem cell differentiation to disease targeted cell types has historically produced poor or inconsistent outcomes.
The Brickman lab recently suggested that pausing differentiation, allowing cells to grow, and catch up at the level of the enhancer network, leads to improved differentiation.
In particular, the Brickman lab has demonstrated that expansion of endoderm at the ventral foregut stage (VFG) increases the efficiency and efficacy of pancreatic endocrine differentiation.
The mech…
KOBENHAVNS UNIVERSITET
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