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EpiCancer focuses on understanding how epigenetic changes influence cancer development and treatment resistance. The project aims to develop advanced methods for analyzing epigenetic modifications at single-cell resolution, which can enhance cancer diagnosis and monitoring through blood tests.
Epigenetic regulation of gene expression- the mechanism responsible for establishing and maintaining cellular identities during development- is frequently deregulated in cancer.
Our working hypothesis is that this deregulation confers upon cells phenotypic plasticity, resulting in intratumor heterogeneity, which is key to tumor development, metastasis, and drug resistance.
In EpiCancer, we seek to provide the technological means to address fundamental issues concerning epigenetics in cancer.
Nam…
WEIZMANN INSTITUTE OF SCIENCE
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