CORDIS Project
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This project explores the role of the epigenome in early cell fate decisions during vertebrate development. By using single-cell multi-omics, it aims to understand how epigenetic changes influence gene activation and lineage specification, providing insights into developmental processes and potential applications in re…
Formation of the three primary germ layers during gastrulation is an essential step in the establishment of the vertebrate body plan.
Single cell RNA-sequencing has identified major transcriptional changes associated with germ layer specification.
Global epigenetic reprogramming accompanies these changes, but the role of the epigenome in regulating early cell fate choice is poorly understood.
We are systematically charting this important developmental progression by single cell multi-omics, trac…
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